Indiana University Purdue University Indianapolis

Horia Petrache Ph.D.

Associate Professor, Physics

Education

1998 Ph.D. Physics, Carnegie Mellon University.

1995 M.S. Physics, Carnegie Mellon University.

1992 Diploma Theoretical Physics, University of Bucharest.

1986 Baccalaureate Mathematics and Physics, ''Dr. I. Mesota'' Lyceum.

Current Research

Measurements of molecular structures and forces by physical methods including X-ray scattering, Nuclear Magnetic Resonance, and osmotic stress. We are located in room LD059 in the basement of the Science Building.

Lab Webpage: http://www.iupui.edu/~lab59/

Select Publications

M. M. Koerner, L. A. Palacio, J. W. Wright, K. S. Schweitzer, B. D. Ray, H. I. Petrache, Electrodynamics of lipid membrane interactions in the presence of zwitterionic buffers. Biophys. J. 101, 362-369.

K. Szymanski, H. I. Petrache, Composite polarizability and the construction of an invariant function of refraction and mass density for solutions. J. Chem. Phys. 134, 144701, 2011.

H. I. Petrache. Lipid Bilayer Structure. In Comprehensive Biophysics, Tamm, L. (Ed.), Elsevier, in press.

Mallikarjunaiah K. J., Leftin A., Kinnun J. J., Justice M. J., Rogozea A. L., Petrache H. I., Brown M. F. 2H NMR shows equivalence of dehydration and osmotic pressures in lipid membrane deformation. Biophys. J., 100, 98-107, 2011. 

Xu F., Zhang H., Ilavsky J., Stanciu L., Ho D., Justice M.J., Petrache H. I., Xie J. Investigation of Catalyst Ink Dispersion Using Both Ultra Small Angle X-Ray Scattering and Cryogenic TEM. Langmuir, 26, 19199-19208, 2010.

D. Danino, E. Kesselman, G. Saper, H. I. Petrache, and D. Harries. Osmotically-induced reversible transitions in lipid-DNA mesophases. Biophys. J.96, L43-45, 2009.

David P. Brownholland, Gabriel S. Longo, Andrey V. Struts, Matthew J. Justice, Igal Szleifer, Horia I. Petrache, Michael F. Brown, David H. Thompson. Phase separation in binary mixtures of bipolar and monopolar lipid dispersions revealed by 2H NMR spectroscopy, small-angle x-ray scattering, and molecular theory. Biophys. J.97, 2700-2709, 2009.

T. K. Rostovtseva, H. I. Petrache, N. Kazemi, E. Hassanzadeh, and S. M. Bezrukov. Interfacial Polar Interactions Affect Gramicidin Channel Kinetics. Biophys. J.94, L23-25, 2008.

H. I. Petrache, D. Harries, and V. A. Parsegian. Measurement of Lipid forces by X-ray Diffraction and Osmotic Stress. In Methods in Membrane Lipids, A. Dopico (ed.), Humana, 2007.

H. I. Petrache and M. F. Brown. X-ray Scattering and Solid-State 2H NMR Probes of Structural Fluctuations in Lipid Membranes. In Methods in Membrane Lipids, A. Dopico (ed.), Humana, 2007.

Petrache I, Fijalkowslka I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR and Tuder RM. Alpha-1 Antitrypsin Inhibits Caspase-3 Activity Preventing Lung Endothelial Cell Apoptosis. Am. J. Pathol. 169 1155-1166, 2006.

Petrache HI, Zemb T, Belloni L, and Parsegian VA (2006). Salt Screening and Specific Ion Adsorption Determine Neutral-Lipid Membrane Interactions. Proc. Natl. Acad. Sci. 103, 7982-7987.

Gondre-Lewis MC, Petrache HI, Wassif CA, Harries D, Parsegian A, Porter FD, and Loh YP (2006). Abnormal Sterols in Cholesterol-Deficiency Diseases Cause Secretory Granule Malformation and Decreased Membrane Curvature. J. Cell Science, 119, 1876-1885.

Petrache HI, Tristram-Nagle S, Harries D, Kucerka N, Nagle JF, and Parsegian VA (2006). Swelling of Phospholipids by Monovalent Salt. J. Lipid Res. 47, 302-309.

For a full list of publications please see http://www.iupui.edu/~lab59/publications.php.

Awards & Honors

Service & Membership

 2007-present     Director, IUPUI Physics Summer Research Program for High School       

                         Students

 2011-present     Member, Science and Society Committee, Indiana Academy of

                         Science

 2008-2011         Chair, Physics and Astronomy section, Indiana Academy of Science

 Awards & Honors

2011                  Trustee’s Teaching Award, IUPUI

2009/2010          The Indiana Section of the American Chemical Society Project SEED Honors

2007/2008          IUPUI Honors Program Research Fellow

2003/2004          Outstanding Mentor Siemens Westinghouse Competition in Math, Science

                         and Technology