Indiana University Purdue University Indianapolis

Bruce David Ray Ph.D.

Associate Scientist, Physics

Education

1983 Ph.D. Biochemistry, Indiana University School of Medicine, Indianapolis, IN.

1970 B.S. Biochemistry, Michigan State University, E. Lansing, MI.

Current Research

Ours is an interdisciplinary research program concerned with the various interactions which occur within an enzyme and between an enzyme and its bound substrate. Magnetic resonance techniques, primarily nuclear magnetic resonance but also including some electron spin resonance, are our main tools for describing these interactions. Most of our experimental studies have involved paramagnetic relaxation enhancement measurements on substrates bound to ATP utilizing enzymes. Our interest in isotopic labeling is a direct outgrowth of our use of nuclear magnetic resonance to describe interactions and is mainly directed to synthesis of specifically labeled ATP's and other substrates of the enzymes we have studied. Our work focuses on finding enzyme and substrate structure in the bound complex.